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inositol monophosphatase
Inositol monophosphatase, commonly referred to as IMPase, is an enzyme of the phosphodiesterase family of enzymes. It is involved in the phosphophatidylinositol () signaling pathway, which affects a wide array of cell functions, including but not limited to, cell growth, apoptosis, secretion, and information processing.〔〕 Inhibition of inositol monophosphatase may be key in the action of lithium in treating bipolar disorder, specifically manic depression.
== Structure ==
The enzyme is a dimer comprising 277 amino acid residues per subunit. Each dimer exists in 5 layers of alternating α-helices and β-sheets, totaling to 9 α-helices and β-sheets per subunit.〔 IMPase has three hydrophilic hollow active sites, each of which bind water and magnesium molecules.〔 These binding sites appear to be conserved in other phosphodiesterases such as fructose 1,6-bisphosphatase (FBPase) and inositol polyphosphate 1-phosphatase.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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